Hydrochloric Acid → 1-((6-chloropyridin-3-yl)methyl)-2,3,5,6,7,8-hexahydro-1H-5,8-epoxyimidazo[1,2-a]azepine-9-carbonitrile

HRID 1043523

반응식

HRID 1043523 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[CH2:13][CH2:12][NH:11][C:10]2=[CH:14][C:15]#[N:16])=[CH:4][CH:3]=1.[CH:17](=[O:22])[CH2:18][CH2:19][CH:20]=O.Cl>C(#N)C>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]2[C:10]3=[C:14]([C:15]#[N:16])[CH:20]4[O:22][CH:17]([N:11]3[CH2:12][CH2:13]2)[CH2:18][CH2:19]4)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 12524ButanedialHCID 743284342-(1-((6-Chloropyridin-3-yl)methyl)imidazolidin-2-ylidene)acetonitrile

생성물 1

HCID 866589441-((6-chloropyridin-3-yl)methyl)-2,3,5,6,7,8-hexahydro-1H-5,8-epoxyimidazo[1,2-a]azepine-9-carbonitrile수율 66%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a 50 ml round bottom flask was added 1.17 g (0.005 mol) 2-(1-((6-chloropyridin-3-yl)methyl)imidazolidin-2-ylidene)acetonitrile, 30 ml dry acetonitrile and 0.860 g (0.01 mol) succinaldehyde and catalytic concentrated HCl. The reaction was stirred at r.t. and monitored by TLC. After completion, the mixture was evaporated to remove solvent and purified by column chromatography to afford final product as faint yellow powder with 66% yield.

후처리

  1. customAfter completion, the mixture was evaporated
  2. customto remove solvent
  3. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-7129a57a4f2f46cd8d13d886b35a99f9
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563546B2

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