N-bromobutanimide → 5-Bromo-4-fluoropyridin-2-amine

HRID 1043767노트

반응식

HRID 1043767 반응식
[Br:1]N1C(=O)CCC1=O.OC(C(F)(F)F)=O.[F:16][C:17]1[CH:22]=[CH:21][N:20]=[C:19]([NH2:23])[CH:18]=1>C(#N)C>[Br:1][C:22]1[C:17]([F:16])=[CH:18][C:19]([NH2:23])=[N:20][CH:21]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 866401984-fluoropyridin-2-amine TFA salt

생성물 1

HCID 579174075-Bromo-4-fluoropyridin-2-amine수율 67.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-Bromosuccinimide (126 mg, 0.71 mmol) was added to a solution of 4-fluoropyridin-2-amine TFA salt (162 mg, 0.72 mmol) in acetonitrile (4 mL) in an aluminum foil-wrapped flask in a darkened hood. The reaction solution was stirred at room temperature in darkness for 2 hours. After evaporation of the solvent, the crude product was purified on a silica gel column eluting with EtOAc to give 5-bromo-4-fluoropyridin-2-amine as an ivory solid (92 mg, 67%). LC/MS (m/z): 190.9/192.9 (MH+), Rt 1.02 minutes.

후처리

  1. customAfter evaporation of the solvent
  2. customthe crude product was purified on a silica gel column
  3. washeluting with EtOAc

출처 및 근거

ORD 기록
ord-42a451ef59bc415baea4b3437f6bb367
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563549B2

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