Hydrochloric Acid → HCID 178419062, 화합물

HRID 10439노트

반응식

HRID 10439 반응식
[C:1]1([CH:7]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]#[N:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3C2CCCCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)C>[C:27]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]#[N:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 101593916-((2,2-Diphenylethyl)amino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile

생성물 1

HCID 178419062HCID 178419062, 화합물수율 99.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 6-[(2,2-diphenylethyl)amino]-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile (Preparation 5) (17 g, 40.1 mmol) in ethanol (850 ml) was treated with 2 N aqueous hydrochloric acid (50 ml) and the mixture stirred at room temperature for 24 hours. The solvent was removed under reduced pressure, the residue dissolved in ethanol and the solvent again removed under reduced pressure. The residue was triturated with diethyl ether, filtered, washed with diethyl ether and pentane, and dried to afford the title compound as a solid (13,6 g).

후처리

  1. customThe solvent was removed under reduced pressure
  2. dissolutionthe residue dissolved in ethanol
  3. customthe solvent again removed under reduced pressure
  4. customThe residue was triturated with diethyl ether
  5. filtrationfiltered
  6. washwashed with diethyl ether and pentane
  7. customdried

출처 및 근거

ORD 기록
ord-a14d829b1b0f421cb9bd657ac37d643a
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094769B2

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