Benzoyl Peroxide → HCID 86686337, 화합물
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[Br:1][C:2]1[C:3]([CH3:10])=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8].C1C(=O)N([Br:18])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]([CH2:10][Br:18])=[N:4][C:5]([CH3:9])=[CH:6][C:7]=1[CH3:8]참가 물질
5
실험 절차
A mixture of 3-bromo-2,4,6-trimethylpyridine (15.6 g), NBS (13.9 g) and benzoyl peroxide (567 mg) was heated under reflux in a carbon tetrachloride solvent (300 mL) for two hours. The reaction mixture was cooled to room temperature and then filtered, and the filtration residue was washed with carbon tetrachloride. The resulting filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%) to give the title compound (3.51 g).
후처리
- temperaturewas heated
- filtrationfiltered
- washthe filtration residue was washed with carbon tetrachloride
- concentrationThe resulting filtrate was concentrated under reduced pressure
- customthe residue was purified by silica gel column chromatography (ethyl acetate/n-heptane, 0% to 10%)
출처 및 근거
- ORD 기록
- ord-2f60003e39714ad08b85ed9ead46deec
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08563565B2
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