Tert-butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate → 4-(Trifluoromethylphenyl)-piperidin-4-ol

HRID 1044575노트

반응식

HRID 1044575 반응식
[OH:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[C:21]([F:24])([F:23])[F:22])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1>Cl.CCOCC>[F:24][C:21]([F:22])([F:23])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:2]1([OH:1])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 49760255Tert-butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate

생성물 1

HCID 226370654-(Trifluoromethylphenyl)-piperidin-4-ol수율 69.3%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3283Diethyl Ether용매2회

실험 절차

tert-Butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate (0.40 g, 1.0 mmol) was dissolved in a 2.0 M solution of HCl in ether (5 mL). After being stirred at room temperature overnight, the solution was diluted with ether. The white solid was filtered and washed with ether to give 170 mg of pure product. MS calculated for C12H14F3NO: (M+H) 246; found 246.1.

후처리

  1. filtrationThe white solid was filtered
  2. washwashed with ether

출처 및 근거

ORD 기록
ord-249b360e20434ab4812c443d0659c7f9
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563582B2

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