Hydrochloric Acid → 2-(Butyloxy)-9-[(1-ethyl-4-piperidinyl)methyl]-9H-purin-6-amine

HRID 1044949노트

반응식

HRID 1044949 반응식
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11](OC)[N:12]2[CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH3:23])[CH2:18][CH2:17]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.O1CCOCC1>CO>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[CH:11][N:12]2[CH2:15][CH:16]2[CH2:17][CH2:18][N:19]([CH2:22][CH3:23])[CH2:20][CH2:21]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58306069HCID 58306069, 화합물

생성물 1

HCID 671825152-(Butyloxy)-9-[(1-ethyl-4-piperidinyl)methyl]-9H-purin-6-amine수율 94.4%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

2-(Butyloxy)-9-[(1-ethyl-4-piperidinyl)methyl]-8-(methyloxy)-9H-purin-6-amine (37 mg, 0.102 mmol) was dissolved in methanol (5 ml) and 4M hydrogen chloride in 1,4-dioxane (0.638 ml, 2.55 mmol) and stirred at rt for 5 hours. The solvent was removed in vacuo to give a white solid. The sample was dissolved in methanol and loaded onto an aminopropyl SPE (2 g), eluting with methanol. The solvent was removed to give the title compound as a white solid (32 mg).

후처리

  1. customThe solvent was removed in vacuo
  2. customto give a white solid
  3. washeluting with methanol
  4. customThe solvent was removed

출처 및 근거

ORD 기록
ord-ae1a8d5bf51a4bc6bed994fff177a42a
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08563717B2

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