Hydrochloric Acid → HCID 59629170, 화합물

HRID 1045303노트

반응식

HRID 1045303 반응식
Br[C:2]1[CH:15]=[CH:14][C:13]2[C:12]3[C:7](=[CH:8][C:9](C4C=CC5C(=CC=CC=5)C=4)=[CH:10][CH:11]=3)[CH:6]=[CH:5][C:4]=2[CH:3]=1.[CH3:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].[CH2:32]([Li])[CH2:33][CH2:34][CH3:35].C([O:40][B:41](OC(C)C)[O:42]C(C)C)(C)C.Cl>C1(C)C=CC=CC=1.C1COCC1>[CH:28]1[C:27]2[C:32](=[CH:33][CH:34]=[CH:35][CH:26]=2)[CH:31]=[CH:30][C:29]=1[C:9]1[CH:8]=[C:7]2[C:6]([C:5]3[CH:14]=[CH:15][C:2]([B:41]([OH:42])[OH:40])=[CH:3][C:4]=3[CH:13]=[CH:12]2)=[CH:11][CH:10]=1

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 8058HexaneHCID 21531Triisopropyl borateHCID 59629216HCID 59629216, 화합물HCID 178418339Butyllithium

생성물 1

HCID 59629170HCID 59629170, 화합물수율 62%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

Under an argon gas atmosphere, a mixture of 15.0 g (39.1 mmol) of 2-bromo-7-(naphthalene-2-yl)phenanthrene and 150 mL of dehydrated THF was cooled down to minus 60 degree C. Then, 30.3 ml (46.7 mmol) of hexane solution of 1.55M n-butyllithium was dropped into the mixture while the mixture was being stirred. The reaction mixture was further stirred at minus 60 degrees for 2 hours. The reaction solution was again cooled down to minus 70 degrees C., and 22.08 g (117.4 mmol) of triisopropylborate was dropped into the solution. The reaction mixture was warmed back to room temperature, stirred for 2 hours and left unattended for one night. Subsequently, the reaction mixture was added with aqueous solution of hydrochloric acid while being cooled on an ice bath, and stirred for 1 hour at room temperature. The reaction mixture was added with toluene, and aqueous phase thereof was eliminated. After organic phase thereof was dried with magnesium sulfate, the solvent was distilled away under reduced pressure. By recrystallizing the obtained solid with toluene-hexane, 8.4 g of 7-(naphthalene-2-yl)phenanthrene-2-ylboronic acid was obtained at an yield of 62%.

후처리

  1. temperaturewas cooled down to minus 60 degree C
  2. stirringThe reaction mixture was further stirred at minus 60 degrees for 2 hours
  3. temperatureThe reaction mixture was warmed back to room temperature
  4. stirringstirred for 2 hours
  5. waitleft
  6. waitunattended for one night
  7. temperaturewhile being cooled on an ice bath
  8. stirringstirred for 1 hour at room temperature
  9. dry with materialAfter organic phase thereof was dried with magnesium sulfate
  10. distillationthe solvent was distilled away under reduced pressure
  11. customBy recrystallizing the obtained solid with toluene-hexane

출처 및 근거

ORD 기록
ord-7e398159eab74cbb848a2002d47c7eb1
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08568903B2

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