Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 2-Nitroacetophenone hydrazone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 2-Nitro-1-phenylethanone | HCID 94833 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Nitroacetophenone hydrazone | HCID 86657893 | 81.1% |
반응 단계
A solution of 2-nitroacetophenone (12.28 g, 0.074 mol) in ethanol (100 mL) was treated with hydrazine hydrate (10.24 g, 0.163 mol) and glacial acetic acid (4.2 mL, 0.074 mol) and the mixture was heated at reflux for 3 hours. The solvent was then evaporated in vacuo. The residue was dissolved in trichloromethane and extracted three times with water to remove the excess of hydrazine hydrate. Evaporation of the organic layer yielded the product (11 g, 0.06 mol, 81%), which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08569259B2 |
| 출처 데이터셋 | uspto-grants-2013_10 |
| ORD ID | ord-f717f6b035134c5f95e546611fba502b |
| 출처 메모 | uspto-grants-2013_10 |