Methyl iodide → HCID 59569552, 화합물

HRID 1045368노트

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HRID 1045368 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[NH:8][C:7](=[O:13])[CH:6]=[CH:5]2.Cl[C:15]1C(C)=C2C(=CC=1)NC(=O)C=C2.C([O-])([O-])=O.[Cs+].[Cs+].IC>CN(C=O)C.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]([CH3:15])[C:7](=[O:13])[CH:6]=[CH:5]2

참가 물질

7

반응물 4

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 58318186HCID 58318186, 화합물HCID 59569575HCID 59569575, 화합물

생성물 1

HCID 59569552HCID 59569552, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

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온도
100 °C

실험 절차

A mixture of 6-chloro-7-methylquinolin-2(1H)-one, 6-chloro-5-methylquinolin-2(1H)-one, Cs2CO3, and iodomethane in DMF was heated in a microwave reactor at 100° C. for 30 min. The mixture was diluted with dichloromethane, washed with water and dried over sodium sulfate. After removing the solvent the crude product (600 mg) was used in the next step without purification. MS (ESI) m/z: Calculated for C11H10ClNO: 207.1. found: 208 (M+H)+.

후처리

  1. washwashed with water
  2. dry with materialdried over sodium sulfate
  3. customAfter removing the solvent the crude product (600 mg)
  4. customwas used in the next step without purification

출처 및 근거

ORD 기록
ord-51a02f2e985d418ea876fd457c311316
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569282B2

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