Acetic Anhydride → N'-(acetyloxy)-4-iodobenzenecarboximidamide

HRID 1045377노트

반응식

HRID 1045377 반응식
[OH:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4].C(N(CC)CC)C.[C:19](OC(=O)C)(=[O:21])[CH3:20]>C(Cl)Cl.C(OC(C)C)(C)C>[C:19]([O:1][N:2]=[C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[NH2:4])(=[O:21])[CH3:20]

참가 물질

6

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 4429393N-Hydroxy-4-iodo-benzamidine

생성물 1

HCID 86663308N'-(acetyloxy)-4-iodobenzenecarboximidamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 7914Diisopropyl Ether용매

실험 절차

To a suspension of the product obtained in Step A above (8.43 g, 32.17 mmol) in 200 ml of CH2Cl2 there are added 6.72 ml (48.2 mmol) of triethylamine. 3.34 ml (35.4 mmol) of acetic anhydride are added dropwise and the solution is stirred overnight at ambient temperature. After washing 3 times with water and then with brine, the organic phase is dried over MgSO4 and evaporated. The solid obtained is taken up in isopropyl ether and then filtered to yield the title product.

후처리

  1. washAfter washing 3 times with water
  2. dry with materialwith brine, the organic phase is dried over MgSO4
  3. customevaporated
  4. customThe solid obtained
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-8dc8ac9c5a664b2bb408d871c4126b8e
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569285B2

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