HCID 824395, 화합물 → HCID 19349977, 화합물
반응식
[C:1]([NH:4][NH:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([I:13])[CH:8]=1)(=O)[CH3:2]>O=P(Cl)(Cl)Cl>[I:13][C:9]1[CH:8]=[C:7]([C:6]2[O:14][C:1]([CH3:2])=[N:4][N:5]=2)[CH:12]=[CH:11][CH:10]=1참가 물질
3
실험 절차
The product obtained in Step A above (2.9 g, 9.54 mmol) is heated at 120° C. for 3 hours in 35 ml of POCl3. After evaporation of POCl3, the residue is taken up in toluene and the mixture is evaporated to dryness again. The residue from evaporation is dissolved in ethyl acetate and the organic phase is washed with, in succession, 10% NaHCO3 solution, water and then brine. The organic phase is dried over MgSO4 to yield, after evaporation, the expected product in the form of a creamy white solid.
후처리
- customAfter evaporation of POCl3
- customthe mixture is evaporated to dryness again
- customThe residue from evaporation
- dissolutionis dissolved in ethyl acetate
- washthe organic phase is washed with, in succession, 10% NaHCO3 solution, water
- dry with materialThe organic phase is dried over MgSO4
- customto yield
- customafter evaporation
출처 및 근거
- ORD 기록
- ord-04d462ce02bc451a82f8f65efa7e4724
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08569285B2
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