Thiourea → 3-Carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide

HRID 1045634노트

반응식

HRID 1045634 반응식
[NH2:1][C:2]([NH2:4])=[S:3].[CH2:5]([O:7][C:8]([C:10]1[C:15]([CH2:16][Br:17])=[N:14][CH:13]=[CH:12][N:11]=1)=[O:9])[CH3:6]>O1CCCC1>[BrH:17].[CH2:5]([O:7][C:8]([C:10]1[C:15]([CH2:16][S:3][C:2](=[NH:4])[NH2:1])=[N:14][CH:13]=[CH:12][N:11]=1)=[O:9])[CH3:6]

참가 물질

4

반응물 2

HCID 2723790ThioureaHCID 667888253-Bromomethyl-pyrazine-2-carboxylic acid ethyl ester

생성물 1

HCID 667889773-Carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide수율 84.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
120 °C

실험 절차

A suspension of thiourea (620 mg) and 3-bromomethyl-pyrazine-2-carboxylic acid ethyl ester (2 g) in tetrahydrofuran was heated in the microwave at 120° C. for 5 minutes. The product formed an oil so the tetrahydrofuran was simply decanted to leave 3-carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide (2.2 g) as an oil. MH+=241, RT=0.26 min (Method A).

후처리

  1. customwas simply decanted

출처 및 근거

ORD 기록
ord-a71f81707b8d4698b12bb5f5ec676672
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569301B2

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