Hydrochloric Acid → 3-Phenylpyrrolidine
반응식
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[C:14]1([CH:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1참가 물질
4
실험 절차
Hydrogen chloride (4N) in ethyl acetate (6 ml) was added to a solution of 1-tertbutoxycarbonyl-3-phenyl-pyrrolidine (1.84 g, 7.4 mmol) in ethyl acetate (2 ml) and the mixture was stirred for 2 hours. After azeotropical removal of the solvent and hydrogen chloride, the residue was partitioned between aqueous potassium carbonate and diethyl ether, and the organic layer was washed with brine, and dried over sodium sulfate. Removal of the solvent afforded 3-phenyl-pyrrolidine (0.95 g, 87%).
후처리
- customAfter azeotropical removal of the solvent and hydrogen chloride
- customthe residue was partitioned between aqueous potassium carbonate and diethyl ether
- washthe organic layer was washed with brine
- dry with materialdried over sodium sulfate
- customRemoval of the solvent
출처 및 근거
- ORD 기록
- ord-488288d0781a4f578c13ada92f70da69
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08569294B2
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