Dimethylformamide dimethyl acetal → HCID 58447035, 화합물

HRID 1045772노트

반응식

HRID 1045772 반응식
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][N:5]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:3]=1.CO[CH:24](OC)[N:25]([CH3:27])[CH3:26]>C1(C)C=CC=CC=1>[Br:8][C:7]1[C:2]([N:1]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:3][C:4]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH2:14]2)=[N:5][CH:6]=1

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 58446994HCID 58446994, 화합물

생성물 1

HCID 58447035HCID 58447035, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A 100 mL round bottom flask was charged with tert-butyl 4-(4-amino-5-bromopyrimidin-2-yl)piperazine-1-carboxylate (2.0 g, 5.6 mmol), N,N-dimethylformamide dimethyl acetal (0.9 g, 7.3 mmol) and toluene (60 mL). The resulting mixture was heated at reflux for 12 h. Work-up: the solvent was evaporated to dryness to afford the product, which was used in the next step without further purification.

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 12 h
  3. customthe solvent was evaporated to dryness
  4. customto afford the product, which
  5. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-33572f8187cf4917a0b1be68b2747ef4
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569300B2

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