Hydrochloric Acid → HCID 178500867, 화합물
반응식
[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5]#[N:6].[OH:8][NH2:9].Cl>C1COCC1>[CH3:1][O:2][C:3](=[O:7])[CH2:4][C:5](=[NH:6])[NH:9][OH:8]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
2-Cyano-acetic acid methyl ester (990 mg, 10 mmol) was dissolved in THF (30 mL). Hydroxy amine (690 mg, HCl salt, 10 mmol) was added thereto, and the mixture was stirred for 2 h at 80° C. After completion of the reaction, 1N HCl was added. The reaction mixture was extracted with EtOAc, and dried over MgSO4. The solvent was removed under reduced pressure, and the residue was used in the next reaction without further purification.
후처리
- additionwas added
- extractionThe reaction mixture was extracted with EtOAc
- dry with materialdried over MgSO4
- customThe solvent was removed under reduced pressure
- customthe residue was used in the next reaction without further purification
출처 및 근거
- ORD 기록
- ord-9a867bf494ad4302ae559000c754ff3d
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08569307B2
반응 노트
불러오는 중…