Cetyl Alcohol → Hexadecyl methanesulfonate

HRID 1046036

반응식

HRID 1046036 반응식
[CH2:1]([OH:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].ClCCl.C(N(C(C)C)CC)(C)C.[CH3:30][S:31](Cl)(=[O:33])=[O:32]>O>[CH3:30][S:31]([O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])(=[O:33])=[O:32]

참가 물질

6

반응물 4

HCID 2682Cetyl AlcoholHCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 81531Diisopropylethylamine

생성물 1

HCID 519810Hexadecyl methanesulfonate수율 97.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

Under an inert atmosphere, e.g., nitrogen, a reactor was charged with 1-hexadecanol 3 (3.78 kg), anhydrous dichloromethane (40 L) and diisopropylethylamine (2.21 kg). The reaction mixture was cooled to −5 to 5° C. and methanesulfonyl chloride (1.87 kg) was added at a controlled rate over 2 hours to ensure that the reaction temperature was kept below 5° C. After the addition was complete, the mixture was warmed to 20 to 30° C. and stirred for one to two hours. The reaction was monitored by GC-MS and was deemed complete when the conversion rate was ≧95%. The reaction was maintained at 20 to 30° C. while being diluted with water (15 L). The organic layer was separated, washed with water (0.50 kg), and concentrated to dryness to yield 4 as a light yellow solid (4.87 kg, 96%). Typical HPLC (AUC) purity was >95%. 1H-NMR was consistent with structure.

후처리

  1. customwas kept below 5° C
  2. additionAfter the addition
  3. temperaturethe mixture was warmed to 20 to 30° C.
  4. temperatureThe reaction was maintained at 20 to 30° C.
  5. customThe organic layer was separated
  6. washwashed with water (0.50 kg)
  7. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-40800cf18da1461cbddd6e3d6addb541
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569321B2

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