Methyl iodide → Methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylate

HRID 1046090노트

반응식

HRID 1046090 반응식
[I:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH2:10]C)=[O:8])[NH:4][N:3]=1.[C:12]([O-])([O-])=O.[K+].[K+].[CH3:18][I:19]>CC#N>[I:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[N:4]([CH3:12])[N:3]=1.[I:19][C:18]1[N:3]([CH3:2])[N:4]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[CH:6]=1

참가 물질

6

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178469149HCID 178469149, 화합물

생성물 2

HCID 46835547Methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylateHCID 58485356HCID 58485356, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of ethyl 3-iodo-1H-pyrazole-5-carboxylate (600 mg, 2.56 mmol) and K2CO3 (609 mg, 4.51 mmol) in dry CH3CN (10 mL) was added MeI (974 mg, 6.77 mmol). The mixture was stirred at room temperature overnight under N2. After TLC showed that starting material had disappeared, the solid was filtered. Solvent was removed and the residue was purified to give methyl 3-iodo-1-methyl-1H-pyrazole-5-carboxylate and methyl 5-iodo-1-methyl-1H-pyrazole-3-carboxylate.

후처리

  1. filtrationthe solid was filtered
  2. customSolvent was removed
  3. customthe residue was purified

출처 및 근거

ORD 기록
ord-5c4af730fc4c4038948decb4ea30eda5
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569292B2

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