Hydrochloric Acid → 1-(2-Chloropyrimidin-5-yl)ethan-1-one

HRID 1046097노트

반응식

HRID 1046097 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([O:10]CC)=[CH2:9])=[CH:4][N:3]=1.Cl>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 143210022-Chloro-5-(1-ethoxyvinyl)pyrimidine

생성물 1

HCID 137157421-(2-Chloropyrimidin-5-yl)ethan-1-one수율 90.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-chloro-5-(1-ethoxyvinyl)pyrimidine (350 mg, 1.9 mmol) in THF (15 mL) was, added aqueous HCl (1N, 15 mL). The mixture was stirred at rt for 4 h, extracted with EtOAc. The organic phase was washed with satd aq NaHCO3 and brine. The combined organic layer was dried over anhydrous Na2SO4 and concentrated to give the crude product, which was purified by prep TLC (PE:EA 3:1) to give 1-(2-chloropyrimidin-5-yl)ethanone (268 mg, yield 90%).

후처리

  1. extractionextracted with EtOAc
  2. washThe organic phase was washed with satd aq NaHCO3 and brine
  3. dry with materialThe combined organic layer was dried over anhydrous Na2SO4
  4. concentrationconcentrated
  5. customto give the crude product, which
  6. customwas purified by prep TLC (PE:EA 3:1)

출처 및 근거

ORD 기록
ord-b0a1778b1c8147f29f11d304aa62e664
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08569292B2

반응 노트

불러오는 중…