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Diisopropylethylamine → 2-(2-Isopropoxy-3-methyl-benzoylamino)-5,6-dimethyl-indan-2-carboxylic acid ethyl ester

HRID 1047744
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HRID 1047744 반응식
[CH:1]([O:4][C:5]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH2:15]([O:17][C:18]([C:20]1([NH2:31])[CH2:28][C:27]2[C:22](=[CH:23][C:24]([CH3:30])=[C:25]([CH3:29])[CH:26]=2)[CH2:21]1)=[O:19])[CH3:16].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[CH2:15]([O:17][C:18]([C:20]1([NH:31][C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[C:13]([CH3:14])[C:5]=2[O:4][CH:1]([CH3:2])[CH3:3])[CH2:28][C:27]2[C:22](=[CH:23][C:24]([CH3:30])=[C:25]([CH3:29])[CH:26]=2)[CH2:21]1)=[O:19])[CH3:16]
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참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 593140882-Isopropoxy-3-methyl-benzoic acidHCID 59314176Ethyl 2-amino-2,3-dihydro-5,6-dimethyl-1H-indene-2-carboxylate

생성물 1

HCID 593142212-(2-Isopropoxy-3-methyl-benzoylamino)-5,6-dimethyl-indan-2-carboxylic acid ethyl ester
수율 94%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2-isopropoxy-3-methyl-benzoic acid (300 mg, 1.54 mmol), 2-amino-5,6-dimethyl-indan-2-carboxylic acid ethyl ester (432 mg, 1.85 mmol), HATU 878 g, 2.31 mmol) in anhydrous DMF (10 mL) is added DIPEA (382 μL, 2.31 mmol). The resulting solution is stirred at RT overnight. After the removal of DMF in vacuo, the residue is dissolved in EtOAc (50 mL) and washed with water (1×10 mL) and brine (2×10 mL). The organic layer is dried over anhydrous Na2SO4 and concentrated in vacuo. The residue is purified by flash column chromatography (115 g silica gel, gradient elution: 5-40% EtOAc in heptane) to give a pure product (90) as white solid (591 mg, 94%).

후처리

  1. customAfter the removal of DMF in vacuo
  2. dissolutionthe residue is dissolved in EtOAc (50 mL)
  3. washwashed with water (1×10 mL) and brine (2×10 mL)
  4. dry with materialThe organic layer is dried over anhydrous Na2SO4
  5. concentrationconcentrated in vacuo
  6. customThe residue is purified by flash column chromatography (115 g silica gel, gradient elution: 5-40% EtOAc in heptane)

출처 및 근거

ORD 기록
ord-c48634ff08cf47a593bb0c028b6c6708
출처 데이터셋
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08569535B2

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