Acetic Acid → (R)-methyl 4-(1-((1-methylcyclohexyl)methylamino)ethyl)benzoate

HRID 1049100노트

반응식

HRID 1049100 반응식
[NH2:1][C@@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].CO.[CH3:16][C:17]1([CH:23]=O)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.C(O)(=O)C.C([BH3-])#N.[Na+]>>[CH3:16][C:17]1([CH2:23][NH:1][C@@H:2]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[CH3:3])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

6

반응물 5

HCID 176Acetic AcidHCID 887MethanolHCID 5003444Sodium cyanoborohydrideHCID 111371681-Methylcyclohexane-1-carboxaldehydeHCID 17751897(R)-Methyl 4-(1-aminoethyl)benzoate

생성물 1

HCID 67395199(R)-methyl 4-(1-((1-methylcyclohexyl)methylamino)ethyl)benzoate수율 63.4%

실험 절차

To a solution of (R)-methyl 4-(1-aminoethyl)benzoate (0.12 g, 0.67 mmol) in methanol (2.97 mL, 73.33 mmol) was added 1-methylcyclohexane-1-carboxaldehyde (0.093 g, 0.74 mmol) and acetic acid (0.152 mL, 2.67 mmol). The reaction was stirred for 1 hour at room temperature whereupon sodium cyanoborohydride (63.1 mg, 1.00 mmol) was added and the mixture further stirred at room temperature overnight. The solvent was evaporated and the residual sodium cyanoborohydride quenched with saturated aqueous NaHCO3. The mixture was extracted into ethyl acetate, the organic layer washed with brine and the solvent evaporated to dryness. The residue obtained was purified via silica chromatography (0-5% MeOH/DCM) to afford the title compound as a colorless oil (123.0 mg, 63%). LC-MS: (FA) ES+ 290.

후처리

  1. additionwas added
  2. customThe solvent was evaporated
  3. customthe residual sodium cyanoborohydride quenched with saturated aqueous NaHCO3
  4. extractionThe mixture was extracted into ethyl acetate
  5. washthe organic layer washed with brine
  6. customthe solvent evaporated to dryness
  7. customThe residue obtained
  8. customwas purified via silica chromatography (0-5% MeOH/DCM)

출처 및 근거

ORD 기록
ord-ef45cbb639e541f79c24a6a042314063
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09382197B2

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