반응식
[CH3:1][O:2][CH2:3]Cl.[Br:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[CH2:9][OH:10].C(N(C(C)C)CC)(C)C.O>C1COCC1>[Br:5][C:6]1[CH:13]=[CH:12][CH:11]=[C:8]([CH2:9][O:10][CH2:1][O:2][CH3:3])[CH:7]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
Under a nitrogen atmosphere, chloromethyl methyl ether (6.09 mL) was added to a solution of 3-bromobenzylalcohol (5.00 g) and diisopropylethylamine (18.9 mL) in THF (45 mL) at 0° C., and the mixture was stirred at 60° C. for 1 hr. Water was added to the reaction mixture at room temperature, and the mixture was extracted with ethyl acetate. The extract was washed with 1N hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a crude product (6.37 g) of the title compound. This compound was used for the next step without further purification.
후처리
- extractionthe mixture was extracted with ethyl acetate
- washThe extract was washed with 1N hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-55033361e52443d3b194c6959dd2f184
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09382188B2
연결된 노트
불러오는 중…