Ammonium Chloride → (3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-oxo-1-octenyI)-2-oxo-5-(phenylmethoxy)hexahydro-2H-cyclopenta[b]furan

HRID 1049953노트

반응식

HRID 1049953 반응식
COP([CH2:7][C:8](=[O:16])[C:9]([F:15])([F:14])[CH2:10][CH2:11][CH2:12][CH3:13])(=O)OC.O[Li].O.[O:20]=[C:21]1[O:25][C@H:24]2[CH2:26][C@@H:27]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C@H:28]([CH:29]=O)[C@H:23]2[CH2:22]1.[NH4+].[Cl-]>CC(OC)(C)C.ClCCl.O>[F:15][C:9]([F:14])([CH2:10][CH2:11][CH2:12][CH3:13])[C:8](=[O:16])/[CH:7]=[CH:29]/[C@@H:28]1[C@@H:23]2[C@@H:24]([O:25][C:21](=[O:20])[CH2:22]2)[CH2:26][C@H:27]1[O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

참가 물질

8

반응물 4

HCID 25517Ammonium ChlorideHCID 168937Lithium hydroxide, monohydrateHCID 11118722Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonateHCID 14460245(3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde

생성물 1

HCID 46862980(3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-oxo-1-octenyI)-2-oxo-5-(phenylmethoxy)hexahydro-2H-cyclopenta[b]furan수율 56%

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매HCID 15413tert-Butyl methyl ether용매

실험 절차

To a solution of dimethyl(3,3-difluoro-2-oxoheptyl)phosphonate (6.9 g, 26.5 mmoL) in MTBE (30 mL) was added LiOH.H2O (1.11 g, 26.5 mmoL) and the mixture was stirred under nitrogen for 1 h. A solution of (3aR,4R,5R,6aS)-hexahydro-2-oxo-5-(phenylmethoxy)-2H-cyclopenta[b]furan-4-carboxaldehyde (6, R1 is phenyl, and R2 and R3 are H, 6 g, 23.1 mmoL) in dichloromethane (30 mL) was added followed by NH4Cl (370 mg, 6.93 mmoL), 0.2 mL water and then the mixture was stirred for 12 h. After completion of the reaction, the reaction was then quenched with a saturated NH4Cl solution (12 mL). The organic layer was separated, washed with brine, dried over Na2SO4 and concentrated to dryness under vacuum. The crude material was further purified by column chromatography [25% ethyl acetate in heptanes] to yield (3aR,4R,5R,6aS)-4-((E)-4,4-difluoro-3-oxo-1-octenyl)-2-oxo-5-(phenylmethoxy)hexahydro-2H-cyclopenta[b]furan (7, R1 is phenyl, and R2 and R3 are H) in 56% yield.

후처리

  1. stirringthe mixture was stirred for 12 h
  2. customAfter completion of the reaction
  3. customthe reaction was then quenched with a saturated NH4Cl solution (12 mL)
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated to dryness under vacuum
  8. customThe crude material was further purified by column chromatography [25% ethyl acetate in heptanes]

출처 및 근거

ORD 기록
ord-706dbbfce2b84e189aa664d8988704f4
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09382272B2

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