Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aniline → 1-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine | HCID 44478903 | — |
| 반응물 | 1-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide | HCID 118090796 | — |
| 생성물 | 1-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamide | HCID 118090798 | 2% |
반응 단계
The procedures of Steps (3) and (4) of Example 2 were repeated step by step, except for using 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine obtained in Step (2) above instead of aniline in Step (3) of Example 1 to obtain the title compound (1.0 mg, 2%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09388165B2 |
| 출처 데이터셋 | uspto-grants-2016_07 |
| ORD ID | ord-f88f749ceefb4e538d8fb2221f7d6f60 |
| 출처 메모 | uspto-grants-2016_07 |