2-Amino-5-chloropyridine → ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate
반응식
[CH2:1]([O:3][C:4]([N:6]=[C:7]=[S:8])=[O:5])[CH3:2].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1>O1CCOCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[S:8])=[N:11][CH:12]=1참가 물질
4
실험 절차
Ethoxycarbonylisothiocyanate (3.37 g) was added to a stirred solution of 2-amino-5-chloropyridine (3.0 g) in dioxane (100 mL). The mixture was stirred at r.t. for 14 h. The solvent was removed in vacuum. The solid was dissolved in dichloromethane and methanol (100:1), filtered and the solvent was removed in vacuum to give a solid that was recrystallized from ethyl acetate to give 4.4 g of the title compound.
후처리
- customThe solvent was removed in vacuum
- dissolutionThe solid was dissolved in dichloromethane
- filtrationmethanol (100:1), filtered
- customthe solvent was removed in vacuum
- customto give a solid
- customthat was recrystallized from ethyl acetate
출처 및 근거
- ORD 기록
- ord-480fe829e8f345e6b252b489f35d79cf
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09388177B2
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