Lithium hydroxide, monohydrate → 2-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

HRID 1051916노트

반응식

HRID 1051916 반응식
[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([O:13]C)=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1.O[Li].O>C1COCC1.CO.O>[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 90303556Methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate

생성물 1

HCID 822769032-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

시약·촉매·용매 1

HCID 21892291Methanol tetrahydrofuran water용매

실험 절차

A mixture of methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (59 mg, 0.28 mmol) and LiOH.H2O (14 mg, 0.33 mmol) in THF/MeOH/H2O (2.5 mL, 3:1:1) was stirred at RT for 2 h. The mixture was acidified to pH=3 and extracted with EtOAc. The comb. org. layers were dried over MgSO4, and conc. in vacuo.

후처리

  1. extractionextracted with EtOAc
  2. dry with materiallayers were dried over MgSO4

출처 및 근거

ORD 기록
ord-05c36b194d0f492d9a17c4ac3aa5227e
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388197B2

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