Iodine → HCID 178422150, 화합물

HRID 1052110노트

반응식

HRID 1052110 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.[I:11]I.[OH-].[K+]>CN(C=O)C.S([O-])([O-])(=O)=S.[Na+].[Na+].O>[I:11][C:10]1[C:4]2[C:5](=[CH:6][N:7]=[C:2]([CH3:1])[CH:3]=2)[NH:8][N:9]=1

참가 물질

7

반응물 3

HCID 807IodineHCID 14797Potassium HydroxideHCID 126684875-methyl-1H-pyrazolo[3,4-c]pyridine

생성물 1

HCID 178422150HCID 178422150, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 24477Sodium Thiosulfate용매

실험 절차

To a solution of 5-methyl-1H-pyrazolo[3,4-c]pyridine [76006-06-9](1.00 g, 7.51 mmol) in DMF (15 mL) were added iodine (2.86 g, 11.3 mmol) and potassium hydroxide (1.05 g, 18.8 mmol). The reaction mixture was stirred at RT for 60 h. The mixture was diluted with 10% sodium thiosulfate and water, the resulting suspension was filtered. The solid was washed with water and dried under vacuum. MS (LC/MS): 260.0 [M+H]+; tR (HPLC conditions d): 0.28 min.

후처리

  1. filtrationthe resulting suspension was filtered
  2. washThe solid was washed with water
  3. customdried under vacuum
  4. custom0.28 min.

출처 및 근거

ORD 기록
ord-93865e07fc454566b6d08724b07853c7
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

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