티오황산 나트륨

Sodium Thiosulfate

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기본 정보

CAS: 7772-98-7
표준 SMILES: O=S([O-])([O-])=S.[Na+].[Na+]
InChIKey: AKHNMLFCWUSKQB-UHFFFAOYSA-L
분자식: Na2O3S2
평균 분자량: 158.11 g/mol
단동위원소 질량: 157.90842442

개요

Sodium thiosulfate is an inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio. It has a role as a nephroprotective agent, an antifungal drug and an antidote to cyanide poisoning. It contains a thiosulfate(2-).

이름 및 식별자

우선 이름: Sodium Thiosulfate
IUPAC: disodium;dioxido-oxo-sulfanylidene-λ6-sulfane
현지명: 티오황산 나트륨
영어명: Sodium thiosulfate
분자식: Na2O3S2
분자량: 158.11

이름 및 동의어

SODIUM THIOSULFATE7772-98-7Sodium thiosulphateDisodium thiosulfateSodothiolHypoChlorine ControlChlorine CureSodium thiosulfate, anhydrousThiosulfuric acid, disodium saltSodium thiosulfate (Na2S2O3)Sodium thiosulphate (Na2S2O3)

이름 더 보기

티오황산염나트륨산화물황화물(NA2S2O3)나트륨하이포아황산염디나트륨티오황산염나트륨티오황산염(NA2S2O3)나트륨티오황산염무수물싸이오황산나트륨티오황산(H2S2O3),디나트륨염티오황산나트륨티오황산,디나트륨염무수티오황산나트륨하이포소듐티오설페이트싸이오황산나트륨(SODIUMTHIOSULFATE)다이소디움 티오설페이트소디움 하이포설파이트싸이오황산 나트륨na2s2o3ThiosulfateSODIUM HYPOSULFITENa2O3S2Sodium ThiosulfiteSodium ThiosulfatSodium Hyposulfite AnhydrousAnhydrous sodium thiosulfate

Sodium oxide sulfide (Na2S2O3)L0IYT1O31NThiosulfuric acid (H2S2O3), disodium saltIns no.539Ins-539Sodium thiosulphate, anhydrousDTXSID9042417CHEBI:132112

데이터베이스 식별자

CAS: 7772-98-7
PubChem CID: 24477
DTXSID: DTXSID9042417
ChEMBL: CHEMBL2096650、CHEMBL3753202
ChEBI: CHEBI:132112
UNII: L0IYT1O31N
EC Number: 231-867-5
Nikkaji: J47.986A

물성

구조 계산 물성보충 중

극성 표면적: 104 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 4
회전 가능 결합 수: 0
무거운 원자 수: 7
형식 전하: 0
복잡도: 82.6

실험 및 물리화학적 성질

Chemical ClassesOther Classes -> Sulfur Compounds

CosmeticsReducing

LogP-4.35 (calculated)

Density · 2건

1.667

1.7 g/cm³

Color/Form · 2건

POWDER

COLORLESS MONOCLINIC CRYSTALS

Solubility · 3건

PRACTICALLY INSOL IN ALCOHOL

50 G SOL IN 100 CC WATER; 231 G @ 100 °C

Solubility in water, g/100ml at 20 °C: 20.9

물리화학적 성질

녹는점: 48 °C · 48°C
끓는 점: 100 °C · 100°C
밀도: 1.01 g/mL · 1.01 g/mL at 25 °C
저장 조건: 5 °C · Store at +5°C to +30°C.
용해도: 알코올과 혼합되지 않습니다.
물리적 상태: 고체
Specific Gravity: 1.667 · 1.667
색상: 하얀색
수소이온지수(pH): 6 · 6.0-8.5 (25℃, 50mg/mL in H2O)
수용성: 물에 용해됩니다. 알코올에 불용성.
Merck: 14 · 14,8694
안정성: 안정적인. 강산, 강산화제, 요오드, 수은과 호환되지 않습니다.
화장품 원료 기능: 피부의 산화 스트레스를 줄이세요
InChI: 1S/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
InChIKey: AKHNMLFCWUSKQB-UHFFFAOYSA-L
SMILES: [Na+].[Na+].[O-]S([O-])(=O)=S
LogP: -0.428 · -0.428 (est)
EPA: Sodium thiosulfate (7772-98-7)

화학적 성질 · 1건

Sodium thiosulfate, Na2S203·5H20, also known as sodium hyposulfite, hypo,andsodium subsulfite, is a white crystalline solid that has a melting point of 48 °C(118 °F). Water soluble,it is used as a fixing agent for photographic films, plates, and papers. Sodium thiosulfate is used in medicine, as a germicide, in manufacturing leather, as a mordant in dyeing, and for extracting silver from ore.

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 2건

Not Classified

Aggregated GHS information provided per 2963 reports by companies from 8 notifications to the ECHA C&L Inventory.

유해성 정보

Regulatory Information · 4건

Chemical: Thiosulfuric acid (H2S2O3), disodium salt

Thiosulfuric acid (H2S2O3), sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiosulfuric acid (H2S2O3), sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14321

Sodium thiosulphate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Thiosulfuric acid (H2S2O3), disodium salt: Environment tier I assessment

Fire HazardsNot combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with oxidizing agents.

Hazards Summary · 1건

Potential combustible dust hazard; Decomposes slowly in water with potential generation of toxic and flammable hydrogen sulfide and corrosive hydrogen sulfite and sulfuric acid; Very soluble in water; Extremely low vapor pressure; May violently decomposes at 223 deg C; [CHEMINFO] ADI = 0-0.7 mg/kg; [JECFA] May be used in food up to 0.1%; [Hawley] See Potassium thiosulfate.

FDA Requirements121.101; LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1%

EPA Safer ChemicalChemical: Sodium thiosulfate

안전 및 보호

Fire FightingIn case of fire in the surroundings, use appropriate extinguishing media.

First Aid Measures · 4건

Fresh air, rest.

Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

Rinse mouth.

Safe StorageSeparated from strong oxidants.

Spillage DisposalPersonal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers.

Eye PreventionWear safety goggles.

Fire PreventionNO contact with oxidizing agents.

독성 정보

Signs and SymptomsRedness.

Human Toxicity ExcerptsREMARKABLY INERT IN VIVO, EXCEPT FOR OSMOTIC DISTURBANCES. ... ACTS AS OSMOTIC CATHARTIC.

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Sodium thiosulfate

vNo-DILI-concern

No match

DOI:10.1016/j.drudis.2016.02.015

규제 정보

FDA Requirements121.101; LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1%

안전 데이터

wgk: 1
tsca: TSCA listed
rtecs: XN6476000
독성: LD50 orally in Rabbit: > 5000 mg/kg
HS 번호: 28323000
risk_code: 36/37/38
hazard_code: Xi
safety_code: 24/25-23-36-26
기존화학 물질: KE-31633
F 고인화성물질: 3
스토리지 클래스: 11 - Combustible Solids
유해 물질 데이터: 7772-98-7(Hazardous Substances Data)

화학 및 산업

약리 정보

ATC CodeV03AB06

Mechanism of Action · 3건

/ANTIFUNGAL ACTION OF SODIUM THIOSULFATE, USP,/...IS PROBABLY ATTRIBUTABLE TO SLOW RELEASE OF COLLOIDAL SULFUR.

IN CYANIDE POISONING, SODIUM NITRITE IS INJECTED IV...TO PRODUCE METHEMOGLOBIN WHICH COMBINES WITH...CYANIDE ION & RENDERS IT TEMPORARILY INACTIVE IN FORM OF CYANMETHEMOGLOBIN. SODIUM THIOSULFATE /USP/ IS THEN INJECTED IV TO FORM NONTOXIC THIOCYANATE.

THIOSULFATE SERVES AS SUBSTRATE FOR ENZYME RHODANESE, WHICH MEDIATES CONVERSION OF CYANIDE TO MUCH LESS TOXIC THIOCYANATE, WHICH IS EXCRETED IN URINE.

MeSH Pharmacological Classification · 4건

Agents counteracting or neutralizing the action of POISONS.

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.

Drugs used in the treatment of tuberculosis. They are divided into two main classes: first-line agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and second-line drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Absorption, Distribution and ExcretionPOORLY ABSORBED FROM BOWEL. ... THIOSULFATE ION DISTRIBUTES ITSELF IN EXTRACELLULAR FLUID.

용도 및 제조

Uses · 6건

It is added in small quantities to ammonium thiosulfate, which is used as a photographic fixing salt. The hydrated salt is used as an anti-chlorine in bleaching, in wastewater purification, for reduction of dichromate in chromed leather production, and as a solvent for silver chloride in the chloride roasting of silver-containing minerals. [Ullmann] Used in paper bleaching, photography (fixer), silver extraction, dyeing textiles (mordant), and leather manufacturing; Also used as an antidote for cyanide poisoning and in vet medicine for bloat and ringworm; [Merck Index]

Pulp and Paper Processing [Category: Industry]

Applying metallic patinas [Category: Hobbies]

TO REMOVE CHLORINE FROM SOLN; AS "ANTICHLOR" IN BLEACHING OF PAPER PULP; FIXER IN PHOTOGRAPHY; MORDANT IN DYEING & PRINTING TEXTILES; REDUCER IN CHROME DYEING, MFR LEATHER; EXTRACTING OF SILVER FROM ORES; BLEACHING BONE, STRAW, IVORY; REAGENT IN ANALYTICAL CHEMISTRY; ANTIDOTE (CYANIDE POISONING)

SEQUESTRANT IN SALT

PHOTOGRAPHIC AGENT TO DISSOLVE SILVER HALIDES; AGENT IN CHROME LEATHER TANNING; ANTICHLOR IN BLEACHING CELLULOSE PRODUCTS; SOURCE OF SULFUR DIOXIDE IN BLEACHING VARIOUS PRODUCTS; PRESERVATIVE; CHEMICAL INTERMEDIATE

U.S. Exports · 3건

(1972) No Data

(1975) No Data

(1984) 6.54X10+9 g /Sodium Sulfite, Bisulfite, Metabisulfite, and Thiosulfate/

U.S. Imports · 3건

(1972) No Data

(1975) 3.44X10+8 GRAMS (INCL SULFITES)

(1984) 9.51X10+9 g /Sodium Sulfite/, Bisulfite, Metabisulfite, and Thiosulfate/

U.S. Production · 3건

2023: 85,000,000 - <100,000,000 lb

(1972) 1.96X10+10 GRAMS

(1975) 1.7X10+10 GRAMS

Consumption Patterns · 2건

90% FOR PHOTOGRAPHY; 5% FOR LEATHER TANNING; 5% FOR CHEMICALS AND MISC APPLICATIONS (1969)

Photographic, 25%; Anitchlor: Paper-25%, Water-20%, Chlor/Alkali-10%; Oil Well Drilling Muds, 10%; Tetramethyl Lead Manufacture, 5%; Other, 5% (1985)

Consumer UsesNot Known or Reasonably Ascertainable

응용 분야 · 3건

용도각종 금속이온과 반응하여 티오 술파이트 착체를 생성하기 때문에 도금욕 중의 금속불순물 제거에 이용된다. 중금속이나 시안화수소의 해독제로써 사용된다. 수돗물의 염소제거제로 사용되기도 한다.

용도Sodium thiosulfate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and sulfide. Other uses are in bleaching paper pulp, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.

일반 설명Sodium thiosulfate (Na2S2O3) can be obtained from Na2S2O3.10H2O by heating above 100 °C. It can be synthesized from sodium sulfate.

제조 방법 · 1건

Sodium thiosulfate is a common reducing agent. It reduces iodine to iodide anion forming sodium tetrathionate. This reaction is utilized in the so-called iodometric titration: 2S2O32ˉ + I2 → S4O62ˉ + 2IˉSodium thiosulfate reacts with chlorine to form sodium bisulfate and hydrochloric acid. This reaction removes chlorine from aqueous solutions:Na2S2O3 + 4Cl2 + 5H2O → 2NaHSO4 + 8HClSodium thiosulfate reacts with hydrochloric acid, decomposing to sulfur and sulfur dioxide: Na2S2O3 + 2HCl → 2NaCl + S + SO2 + H2O.

상·하류 제품 정보

상류 원료

유황 황화나트륨 아황산나트륨 이산화 황 Sulphur Black 1 타르타르산 칼륨 나트륨 오산화 바나듐 염산 유황 수산화나트륨 티오황산 나트륨 펜타수화물 황화 바륨

하류 제품

4-[4-(브로모메틸)페닐]-1,2,3-티아디아졸 3-Fluoro-2-iodopyridine-4-carboxylic acid 4-Fluorothiophenol S-Methyl-S-(4-methoxyphenyl) sulfoximine 요오드시클로헥산 S-Methyl-S-(5-methylfuran-2-yl) sulfoximine S-Methyl-S-(4-hydroxyphenyl) sulfoximine 2,5-Dibromo-3-nitropyridine Insecticide double agent 1-Adamantanol 4-(Chlorosulfonyl)-7-fluoro-2,1,3-benzoxadiazole S-Methyl-S-(2-thiazyl) sulfoximine

추가 설명

정의ChEBI: An inorganic sodium salt composed of sodium and thiosulfate ions in a 2:1 ratio.

화합물 노트

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기본 정보

CAS: 7772-98-7
표준 SMILES: O=S([O-])([O-])=S.[Na+].[Na+]
InChIKey: AKHNMLFCWUSKQB-UHFFFAOYSA-L
분자식: Na2O3S2
평균 분자량: 158.11 g/mol
단동위원소 질량: 157.90842442

개요