Hydrochloric Acid → (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester hydrochloride

HRID 1052126노트

반응식

HRID 1052126 반응식
C(OC([N:8]1[C@H:13]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:12][C@@H:11]2[C@H:9]1[CH2:10]2)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH2:17]([O:16][C:14]([C@@H:13]1[CH2:12][C@@H:11]2[C@@H:9]([CH2:10]2)[NH:8]1)=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68283955(1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-benzyl ester 2-tert-butyl ester

생성물 1

HCID 90020119(1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of (1R,3S,5R)-2-aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 3-benzyl ester 2-tert-butyl ester (2.69 g, 8.48 mmol) in dioxane was added HCl (4N in dioxane, 10.6 mL, 42.4 mmol). The reaction mixture was stirred at RT overnight and subsequently lyophilized. MS (LC/MS): 218 [M+H]+.

출처 및 근거

ORD 기록
ord-7fb6556ea5b347308af4419dd92b0ec9
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

반응 노트

불러오는 중…