Hydrochloric Acid → (S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

HRID 1052136노트

반응식

HRID 1052136 반응식
C(OC(=O)[NH:7][C@H:8]([CH2:14][OH:15])[CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[NH2:7][C@@H:8]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:14][OH:15]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58280489((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester

생성물 1

HCID 90020033(S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a solution of ((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester (200 mg, 0.605 mmol) in dioxane (4 mL) was added HCl (4N in dioxane, 6.05 mL, 24.21 mmol). The reaction mixture was stirred at RT overnight and concentrated to give the desired material as a white powder which was used without further purification in the next. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.79 (bs, 3H), 5.37 (m, 1H), 3.60 (m, 1H), 3.40 (overlap with water, m, 1H), 3.09 (m, 1H), 1.47 (dd, 1H), 1.33 (dd, 1H), 0.92 (s, 9H).

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b8f75b3ea9843b1b6394e40b5659b2f
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388199B2

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