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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Cesium fluoride → (S)-2-(1-((6-Amino-5-iodopyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

HRID 1052348
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HRID 1052348 반응식
[NH2:1][C@H:2]([C:4]1[N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:8](=[O:16])[C:7]2=[C:17]([CH3:20])[CH:18]=[CH:19][N:6]2[N:5]=1)[CH3:3].Cl[C:22]1[N:27]=[CH:26][N:25]=[C:24]([NH2:28])[C:23]=1[I:29].[F-].[Cs+].C(N(CC)C(C)C)(C)C>>[NH2:28][C:24]1[N:25]=[CH:26][N:27]=[C:22]([NH:1][C@H:2]([C:4]2[N:9]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[C:8](=[O:16])[C:7]3=[C:17]([CH3:20])[CH:18]=[CH:19][N:6]3[N:5]=2)[CH3:3])[C:23]=1[I:29]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 25953Cesium fluorideHCID 81531DiisopropylethylamineHCID 468558336-Chloro-5-iodopyrimidin-4-amineHCID 90102580(S)-2-(1-Aminoethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

생성물 1

HCID 118433756(S)-2-(1-((6-Amino-5-iodopyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one수율 59.1%

실험 절차

(S)-2-(1-Aminoethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (0.55 g, 2.05 mmol) was treated with 6-chloro-5-iodopyrimidin-4-amine (1 g, 3.29 mol), cesium fluoride (0.62 g, 4.08 mmol), N,N-diisopropylethylamine (1.79 mL, 10.28 mol) according to Preparation 13. The residue was purified using SP1® Purification System (0% to 100%, hexane-ethyl acetate) to give 0.59 g (59% yield) of the title compound as a solid. Purity 100%.

후처리

  1. customaccording to Preparation 13
  2. customThe residue was purified
  3. customSP1® Purification System (0% to 100%, hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-f353c6e709fb4af48a401ac391cf24eb
출처 데이터셋
uspto-grants-2016_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09388189B2

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