Sodium Hydroxide → 3-bromo-N-phenyl-1H-pyrrole-2-carboxamide

HRID 1052352노트

반응식

HRID 1052352 반응식
[Br:1][C:2]1[CH:6]=[CH:5][N:4](S(C2C=CC=CC=2)(=O)=O)[C:3]=1[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17].[OH-].[Na+]>CO>[Br:1][C:2]1[CH:6]=[CH:5][NH:4][C:3]=1[C:16]([NH:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 709789713-Bromo-N-phenyl-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide

생성물 1

HCID 709788613-bromo-N-phenyl-1H-pyrrole-2-carboxamide수율 64.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-bromo-N-phenyl-1-(phenylsulfonyl)-1H-pyrrole-2-carboxamide (2.70 g of crude material) in 50 mL of methanol was added 15 mL of an aqueous 1N solution of sodium hydroxide and the mixture was stirred at room temperature during 1.5 h. At the end of this period, no starting material was detected and the reaction was elaborated in the following way: methanol was evaporated and a precipitate was formed which was filtered off and washed several times with water. The solid was dried in the vacuum oven to afford 1.14 g of the title compound that was used in the following step without any further purification.

후처리

  1. custommethanol was evaporated
  2. customa precipitate was formed which
  3. filtrationwas filtered off
  4. washwashed several times with water
  5. customThe solid was dried in the vacuum oven

출처 및 근거

ORD 기록
ord-f0848885d07d4acaa3a6f4e905c17f1b
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09388189B2

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