Triphenylphosphine → 2-chloro-9H-carbazole

HRID 1052920노트

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HRID 1052920 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-])=O)=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>ClC1C=CC=CC=1Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:14][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 2355494'-Chloro-2-nitro-1,1'-biphenyl

생성물 1

HCID 27523882-chloro-9H-carbazole수율 93.2%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

Next, a mixed solution of 22 g of 2-(4-chlorophenyl)nitrobenzene, 61 g of triphenylphosphine and 190 ml of o-dichlorobenzene was refluxed for 6 hours under a nitrogen flow. The solution was cooled to room temperature, o-dichlorobenzene was then distilled away under reduced pressure, and the concentrate was purified by silica gel column chromatography, and vacuum-dried to obtain 17.7 g of 2-chloro-9H-carbazole.

후처리

  1. distillationo-dichlorobenzene was then distilled away under reduced pressure
  2. customthe concentrate was purified by silica gel column chromatography
  3. customvacuum-dried

출처 및 근거

ORD 기록
ord-c705fbb6b51943989e25bee17650b5b6
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09391288B2

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