Hydrazine hydrate (1:1) → tert-Butyl (S)-(1-(aminooxy)propan-2-yl)carbamate

HRID 1053348노트

반응식

HRID 1053348 반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[O:12][CH2:13][C@@H:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH3:15].O.NN>C(O)C.C(Cl)Cl>[NH2:3][O:12][CH2:13][C@@H:14]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH3:15]

참가 물질

5

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 86693954tert-Butyl {(1S)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-1-methylethyl}carbamate

생성물 1

HCID 39238211tert-Butyl (S)-(1-(aminooxy)propan-2-yl)carbamate수율 77.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

To a solution of tert-butyl {(1S)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-1-methylethyl}carbamate 58 (1.2 g, 3.74 mmol) in a mixture of ethanol (3 mL) and DCM (20 mL) was added hydrazine hydrate (0.215 mL, 3.74 mmol). The reaction mixture was stirred at room temperature for 6 h. Precipitate was filtered off, the filtrate was evaporated and the residue was subjected to chromatography to give 59 (0.55 g, 77%) as a white solid.

후처리

  1. filtrationPrecipitate was filtered off
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-413534b9a7b64255a6c7c3ee5f78b0fb
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09393239B2

반응 노트

불러오는 중…