Hydrazine hydrate (1:1) → N4-(6-aminohexahydrofuro[3,2-b]furan-3-yl)-5-chloro-N2-(1-methyl-1H-pyrazol-4-yl)pyrimidine-2,4-diamine

To a solution of 2-(6-((5-chloro-2-((l-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)isoindoline-1,3-dione (140.0 mg, 0.29 mmol) in EtOH (5 mL) was added hydrazine hydrate (198.6 mg, 2.94 mmol). The mixture was stirred at room temperature for 4 h. The mixture was concentrated in vacuo, the residue was purified with a silica gel column chromatography ((7M NH3 in MeOH)/DCM (v/v)=1/20) to give the target product as a white solid (65.0 mg, 63.6%).