Phosphorus tribromide → 4-(Bromomethyl)-2-(trifluoromethyl)thiazole

HRID 1054227

반응식

HRID 1054227 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[S:4][CH:5]=[C:6]([CH2:8]O)[N:7]=1.P(Br)(Br)[Br:13]>C(Cl)Cl>[Br:13][CH2:8][C:6]1[N:7]=[C:3]([C:2]([F:11])([F:10])[F:1])[S:4][CH:5]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

생성물 1

HCID 694413474-(Bromomethyl)-2-(trifluoromethyl)thiazole수율 36%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirring solution of (2-(trifluoromethyl)thiazol-4-yl)methanol (550 mg, 3.00 mmol) in DCM (5 ml) was added PBr3 (0.283 ml, 3.00 mmol) at 0-5° C. in 5-10 min. and stirring continued for 1 h. Reaction mixture was diluted with DCM and washed with water. Organic layer was separated and distilled out to get crude product which was column purified using 0-2% EtOAC in hexane to get title compound in 36% yield.

후처리

  1. customReaction mixture
  2. washwashed with water
  3. customOrganic layer was separated
  4. distillationdistilled out
  5. customto get crude product which
  6. custompurified

출처 및 근거

ORD 기록
ord-b2c90fe60bc649b0aa3bc4837e7703bb
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394300B2

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