Acetyl chloride → HCID 58994978, 화합물
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2([C:16]#[N:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:18][C:19](Cl)=[O:20].CCN(C(C)C)C(C)C>C(Cl)Cl>[C:19]([N:13]1[CH2:14][CH2:15][C:10]([C:7]2[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)([C:16]#[N:17])[CH2:11][CH2:12]1)(=[O:20])[CH3:18]참가 물질
5
실험 절차
A solution of 4-(4-nitro-phenyl)-piperidine-4-carbonitrile (as prepared in the previous step) in CH2Cl2 is treated with CH3COCl and DIEA. The mixture is washed with water, and the organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.
후처리
- washThe mixture is washed with water
- dry with materialthe organic layer is dried (MgSO4)
- concentrationconcentrated in vacuo
- customThe residue is purified by silica gel chromatography with the appropriate solvent
출처 및 근거
- ORD 기록
- ord-514b8fb878e147c4a0f94be54cb85c1c
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09394289B2
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