Sodium borohydride → 2-(2,5-Difluorophenyl)pyrrolidine
반응식
[BH4-].[Na+].[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[C:11]1[CH2:12][CH2:13][CH2:14][N:15]=1>CO.O>[F:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH:11]1[CH2:12][CH2:13][CH2:14][NH:15]1참가 물질
4
실험 절차
NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound. MS (ESI): m/z 184 (M+H).
후처리
- customThe reaction mixture was quenched with 1N aqueous HCl solution
- extractionextracted with DCM
- dry with materialdried over anhydrous sodium sulphate
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-a949c2660c104268b9ea8f14c6ca24fc
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09394305B2
반응 노트
불러오는 중…