Pyruvic Acid → 7-Chloro-3-methylquinoxalin-2(1h)-one

HRID 1055031노트

반응식

HRID 1055031 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.O=[C:11]([CH3:15])[C:12](O)=[O:13]>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:12](=[O:13])[C:11]([CH3:15])=[N:9]2.[Cl:1][C:2]1[CH:3]=[C:4]2[C:5]([N:8]=[C:11]([CH3:15])[C:12](=[O:13])[NH:9]2)=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 1060Pyruvic AcidHCID 72634-Chloro-1,2-diaminobenzene

생성물 2

HCID 2581487-Chloro-3-methylquinoxalin-2(1h)-one수율 148.1%HCID 11636992HCID 11636992, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

4-chlorobenzene-1,2-diamine (5 g, 35.1 mmol, Eq: 1.00) was stirred in water (50 ml) at room temperature. 2-Oxopropanoic acid (3.09 g, 2.44 ml, 35.1 mmol, Eq: 1.00) in water (20 ml) was added drop wise. The dark mixture was stirred at room temperature for 30 min. The precipitate was filtered off and washed with water and dried under high vacuum to give 6-chloro-3-methyl-1H-quinoxalin-2-one with 7-chloro-3-methyl-1H-quinoxalin-2-one (5.06 g, 37.1%) as brown solid. MS: m/z=195.03 (M+H+)

후처리

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-0fca87ee4d614167b080439c3007499c
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394311B2

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