2-(Difluoromethoxy)naphthalene-1-carbaldehyde → [2-(Difluoromethoxy)naphthalen-1-yl]methanol
반응식
[BH4-].[Na+].[F:3][CH:4]([F:18])[O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]=1[CH:16]=[O:17]>CCO.O>[F:3][CH:4]([F:18])[O:5][C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]=1[CH2:16][OH:17]참가 물질
5
실험 절차
NaBH4 (255 mg, 6.73 mmol) was added to a suspension of 2-(difluoromethoxy)-1-naphthaldehyde (0.997 g, 4.49 mmol) in EtOH (29.9 mL). After 3 h the mixture was diluted with H2O, extracted with EtOAc, the combined extracts were washed with brine (200 mL), dried over Na2SO4, filtered, and the filtrate concentrated to give a residue that was purified by silica gel chromatography to provide (2-(difluoromethoxy)naphthalen-1-yl)methanol (387 mg, 39%) as an orange solid.
후처리
- extractionextracted with EtOAc
- washthe combined extracts were washed with brine (200 mL)
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationthe filtrate concentrated
- customto give a residue that
- customwas purified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-331b8d17532b4ac585ee90dc9feafdcb
- 출처 데이터셋
- uspto-grants-2016_07
- 특허 번호
- US09394263B2
반응 노트
불러오는 중…