Hydrochloric Acid → Cannabigerolic Acid

HRID 1055494노트

반응식

HRID 1055494 반응식
CN([CH:4]=[O:5])C.[CH3:6]/[C:7](/[CH2:23][CH2:24][CH:25]=[C:26]([CH3:28])[CH3:27])=[CH:8]\[CH2:9][C:10]1[C:15]([OH:16])=[CH:14][C:13]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:12][C:11]=1[OH:22].Cl.C(Cl)(Cl)Cl.C[OH:35]>>[CH3:21][CH2:20][CH2:19][CH2:18][CH2:17][C:13]1[CH:14]=[C:15]([OH:16])[C:10]([CH2:9]/[CH:8]=[C:7](/[CH2:23][CH2:24][CH:25]=[C:26]([CH3:27])[CH3:28])\[CH3:6])=[C:11]([OH:22])[C:12]=1[C:4]([OH:5])=[O:35]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 5315659CannabigerolHCID 21584188Chloroform methanol

생성물 1

HCID 6449999Cannabigerolic Acid

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온도
120 °C

실험 절차

6-carboxylic acid-2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol, Cannabigerolic Acid (CBGA) was prepared as follows. To a 10 mL conical flask was added 1 mL of a DMF solution of MMC. To this solution was added 2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentyl-benzene-1,3-diol (120 mg, 0.379 mmol). The flask was heated at 120° C. for 1 hour, following which the reaction mixture was dissolved in 100 mL of chloroform:methanol (2:1) solution. The pH of this solution was adjusted with dilute HCl to pH 2.0, and then partitioned using 50 mL H2O.

후처리

  1. custompartitioned

출처 및 근거

ORD 기록
ord-261d3e1095cb46be978e044c17a44d25
출처 데이터셋
uspto-grants-2016_07
특허 번호
US09394510B2

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