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Hydrochloric Acid → 2-amino-N-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)acetamide hydrochloride

HRID 1056519
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HRID 1056519 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[N:16]([CH2:17][CH2:18][NH:19][C:20](=[O:30])[CH2:21][NH:22]C(=O)OC(C)(C)C)[C:15](=[S:31])[NH:14][C:13](=[O:32])[CH:12]=1.[ClH:33]>C(OCC)(=O)C>[ClH:33].[NH2:22][CH2:21][C:20]([NH:19][CH2:18][CH2:17][N:16]1[C:11]([C:4]2[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=2[O:2][CH3:1])=[CH:12][C:13](=[O:32])[NH:14][C:15]1=[S:31])=[O:30]
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86684683tert-butyl 2-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)ethylamino)-2-oxoethylcarbamate

생성물 1

HCID 866846842-amino-N-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)acetamide hydrochloride수율 100%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of tert-butyl 2-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)ethylamino)-2-oxoethylcarbamate (70 mg, 0.15 mmol) in ethyl acetate (2 mL) was added a solution of HCl in ethyl acetate (2 mL). After stirring at room temperature for 4 hours, the reaction mixture was concentrated under reduced pressure to afford the desired 2-amino-N-(2-(6-(2,4-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl)acetamide hydrochloride as a solid (65 mg, 100%).

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-11ccb28474bc4c55b66abb67e53627cc
출처 데이터셋
uspto-grants-2016_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09399626B2

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