참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Methyl-3-nitrobenzotrifluoride | HCID 1472885 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Hexane | HCID 8058 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 6-Trifluoromethyloxindole | HCID 608487 | — |
반응 단계
Dimethylsulfoxide (330 mL) was added to 7.9 g of sodium hydride followed by, dropwise, 43.6 g of diethyloxalate. The mixture was heated to 100° C. for 1 hour and cooled to room temperature. 2-Nitro-4-trifluromethyltoluene (31.3 g) was added, the reaction stirred for 30 minutes at room temperature and then heated to 100° C. for 1 hour. The reaction was cooled and poured into a mixture of saturated aqueous ammonium chloride, ethyl acetate and hexane. The organic layer was washed with saturated ammonium chloride, water and brine, dried, and concentrated to give dimethyl
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06514981B1 |
|---|
| 출처 데이터셋 | uspto-grants-2003_02 |
|---|
| ORD ID | ord-7cf27e07f26d4d12827b8af62e66dd4a |
|---|
| 출처 메모 | uspto-grants-2003_02 |
|---|
