反应详情

温度

100 °C

Dimethylsulfoxide (330 mL) was added to 7.9 g of sodium hydride followed by, dropwise, 43.6 g of diethyloxalate. The mixture was heated to 100° C. for 1 hour and cooled to room temperature. 2-Nitro-4-trifluromethyltoluene (31.3 g) was added, the reaction stirred for 30 minutes at room temperature and then heated to 100° C. for 1 hour. The reaction was cooled and poured into a mixture of saturated aqueous ammonium chloride, ethyl acetate and hexane. The organic layer was washed with saturated ammonium chloride, water and brine, dried, and concentrated to give dimethyl

1. temperaturecooled to room temperature
2. temperatureheated to 100° C. for 1 hour
3. temperatureThe reaction was cooled
4. washThe organic layer was washed with saturated ammonium chloride, water and brine
5. customdried
6. concentrationconcentrated
7. customto give dimethyl