Bromoacetic Acid → 2-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid

HRID 1057481

반응식

HRID 1057481 반응식
Br[CH2:2][C:3](O)=[O:4].[NH:6]1[C:11]2=[N:12][C:13]([CH2:16][CH2:17][CH2:18][NH2:19])=[CH:14][CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7]1.[CH:20]1([CH2:31][C:32]([O:34]C)=[O:33])[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[CH2:24][CH2:23][NH:22][CH2:21]1>>[NH:6]1[C:11]2=[N:12][C:13]([CH2:16][CH2:17][CH2:18][NH:19][C:3]([CH2:2][N:22]3[CH2:23][CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[CH:20]([CH2:31][C:32]([OH:34])=[O:33])[CH2:21]3)=[O:4])=[CH:14][CH:15]=[C:10]2[CH2:9][CH2:8][CH2:7]1

참가 물질

4

반응물 3

HCID 6227Bromoacetic AcidHCID 98775993-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amineHCID 18671414HCID 18671414, 화합물

생성물 1

HCID 99327572-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid

실험 절차

2-(3-{[N-(3-(1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-yl)propyl)carbamoyl]methyl}-1H,2H,4H,5H-benzo[d]azepinyl)acetic acid was prepared from bromoacetic acid, 3-(1,2,3,4-tetrahydropyridino[2,3,b]pyridin-7-yl)propylamine and methyl 2-(1H,2H,3H,4H,5H-benzo[d]azepin-1-yl)acetate according to the procedure of Example 27. EI-MS m/z 437 (M+H)+; 1H NMR (400 MHz; CDCl3): 9.61 (1H, br), 8.39 (1H, br), 7.15 (5H, m), 6.31 (1H, d, J=7.25 Hz), 3.64 (2H, m), 3.34 (6H, m), 2.99 (4H, m), 2.71 (4H, m), 1.93 (5H, m), 0.86 (2H, m).

출처 및 근거

ORD 기록
ord-814bff23bce74268ab43ea2ae5b91b88
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514964B1

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