Phthalic Anhydride → 2-Pyrimidin-4-yl-indan-1,3-dione

HRID 1057719

반응식

HRID 1057719 반응식
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][N:14]=1>CO>[N:16]1[CH:17]=[CH:18][C:13]([CH:12]2[C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])=[N:14][CH:15]=1

참가 물질

4

반응물 2

HCID 6811Phthalic AnhydrideHCID 189224-Methylpyrimidine

생성물 1

HCID 126190852-Pyrimidin-4-yl-indan-1,3-dione

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7.87 g (53.1 mmol) phthalic acid anhydride and 22 ml (0.24 mol) 4-methylpyrimidine are stirred for 1 h at 140° C. and for 4 h at 210° C. The reaction mixture is then stirred with 15 ml methanol, filtered, and the residue washed with methanol. Further product is obtainable by evaporating the filtrate and stirring the residue with water m.p.: 168-169° C.); Anal. calc.(C13H8N2O2) C, 69.64%; H, 3.60%; N, 12.49%; found C, 69.8%; H 3.7%; N, 12.4%; FAB MS (M+H)+=225.

후처리

  1. filtrationfiltered
  2. washthe residue washed with methanol
  3. customby evaporating the filtrate

출처 및 근거

ORD 기록
ord-17205e8268a04b8b8224c732d68756a4
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514974B2

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