Hydrochloric Acid → 7-Methoxy-1-benzofuran-2-carbaldehyde

HRID 1057934노트

반응식

HRID 1057934 반응식
[C:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)#N.CC(C[AlH]CC(C)C)C.C[OH:24].Cl>ClCCl.C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[C:5]2[O:4][C:3]([CH:1]=[O:24])=[CH:7][C:6]=2[CH:8]=[CH:9][CH:10]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14487Diisobutylaluminum hydrideHCID 2985567-Methoxybenzofuran-2-carbonitrile

생성물 1

HCID 34573107-Methoxy-1-benzofuran-2-carbaldehyde

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6344Dichloromethane용매

실험 절차

2-Cyano-7-methoxybenzofuran (0.736 g) was dissolved in dichloromethane (10 ml), and a 1.02N DIBAL solution (5.4 ml) in toluene was added thereto at −4 to −30° C., followed by stirring for one hour. Methanol and dilute hydrochloric acid were added to the mixture, and the solvent was distilled off. The obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1) to give Compound IIad-a (0.371 g, 50%) as an oily substance.

후처리

  1. customat −4 to −30° C.
  2. distillationthe solvent was distilled off
  3. customThe obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1)
  4. customto give Compound IIad-a (0.371 g, 50%) as an oily substance

출처 및 근거

ORD 기록
ord-9e9b1694743a4449b93ddf0f1ade65b4
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06514996B2

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