2-Chloropyridine → 2-(N-Methyl-N-(2-pyridyl)amino)ethanol

HRID 1058088노트

반응식

HRID 1058088 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:8][NH:9][CH2:10][CH2:11][OH:12]>>[CH3:8][N:9]([CH2:10][CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 79772-ChloropyridineHCID 80162-(Methylamino)ethanol

생성물 1

HCID 7374202-(N-Methyl-N-(2-pyridyl)amino)ethanol

실험 절차

The reaction of 2-chloropyridine with 2-(N-methyl amino)ethanol provides 2-(N-methyl-N-(2-pyridyl)amino)ethanol (II), which on coupling reaction with 4-fluorobenzaldehyde (III) in an aprotic polar solvent with an alkali metal hydroxide or an alkali metal alkoxide as base yields 4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzaldehyde (IV) with an 88% yield (Reaction I).

출처 및 근거

ORD 기록
ord-e58b72df1612415e90e00bb4f473b1d1
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515132B2

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