Potassium Carbonate → HCID 178505549, 화합물

HRID 1058099노트

반응식

HRID 1058099 반응식
C([O-])([O-])=O.[K+].[K+].[F:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[NH:13])=[CH:10][CH:9]=1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=1)=O>C(Cl)(Cl)Cl>[F:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]2[NH:14][CH:18]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[N:13]=2)=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromideHCID 42952384-Fluorobenzamidine

생성물 1

HCID 178505549HCID 178505549, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a two-phase mixture of 30% K2CO3 solution (5 ml) and chloroform (5 mL) containing 276 mg of 4-fluorobenzamidine was added a solution of 468 mg of 2-bromo-4′-chloroacetophenone in chloroform (3 mL). After stirring for 1 hr, the reaction mixture was filtered. The white crystallinesolid was washed with distilled water and dried in a vacuum oven overnight to afford 2-(4-fluorophenyl)4-(4-chlorophenyl)imidazole (Compound 1).

후처리

  1. filtrationthe reaction mixture was filtered
  2. washThe white crystallinesolid was washed with distilled water
  3. customdried in a vacuum oven overnight

출처 및 근거

ORD 기록
ord-95830806431743d0a9e059227e35a0a9
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06515133B1

반응 노트

불러오는 중…