Iodoethane → ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate

HRID 1058683노트

반응식

HRID 1058683 반응식
[CH3:1][C:2]1[N:6]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=[O:10])[N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:22](I)[CH3:23]>CC(C)=O>[CH3:1][C:2]1[N:6]([C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([O:11][CH2:22][CH3:23])=[O:10])[N:5]=[N:4][N:3]=1

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 121328602-(5-Methyl-1H-tetrazol-1-yl)nicotinic acid

생성물 1

HCID 12132861ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-(5-Methyl-1H-tetrazol-1-yl)nicotinic acid (5.6 g, 27 mmole) was suspended in acetone (250 mL), potassium carbonate (5 g) and ethyl iodide (5 mL) were added and the reaction mixture was heated at reflux for 2 hours. The acetone was removed under vacuum. The residue was partitioned between water and dichloromethane. The dichloromethane layer was separated, dried, then concentrated under vacuum to provide 6.3 g of ethyl 2-(5-methyl-1H-tetrazol-1-yl)nicotinate.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 2 hours
  3. customThe acetone was removed under vacuum
  4. customThe residue was partitioned between water and dichloromethane
  5. customThe dichloromethane layer was separated
  6. customdried
  7. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-9230a040c2174b0dac73e762ccbba45f
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518280B2

반응 노트

불러오는 중…