Sodium Iodide → 3-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enal

HRID 1059032

반응식

HRID 1059032 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH:8]=[O:9])=[CH:4][C:3]=1[O:12][CH3:13].[CH2:14](Cl)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])([O-])=O.[K+].[K+].[Na+].[I-]>CC(C)=O>[CH2:14]([O:1][C:2]1[CH:11]=[CH:10][C:5]([CH:6]=[CH:7][CH:8]=[O:9])=[CH:4][C:3]=1[O:12][CH3:13])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 7503Benzyl ChlorideHCID 99842-Propenal, 3-(4-hydroxy-3-methoxyphenyl)-HCID 11430Potassium Carbonate

생성물 1

HCID 537901463-(3-Methoxy-4-phenylmethoxyphenyl)prop-2-enal수율 85%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Hydroxy-3-methoxycinnamaldehyde (0.6 g) was added to the mixture of benzyl chloride (1 mL), K2CO3 (1 g), and NaI (1 g) in acetone (20 mL). The resulting mixture was stirred at room temperature for 24 hrs. The solid were removed by filtration and washed with acetone. After evaporation of solvent, the crude product was purified by gradient chromatography to give a yellowish solid. Yield 85%.

후처리

  1. customThe solid were removed by filtration
  2. washwashed with acetone
  3. customAfter evaporation of solvent
  4. customthe crude product was purified by gradient chromatography
  5. customto give a yellowish solid

출처 및 근거

ORD 기록
ord-fbb54ea6072e472ebc9d8fcc69187f33
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518315B1

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